The Antihyperplastic Effect of Oral Catechin Ingestion in a Rat Model of Benign Prostatic Hyperplasia.
10.4111/kju.2006.47.12.1289
- Author:
Duk Jin PARK
1
;
Sung Hak KANG
;
Yong Hyun CHO
Author Information
1. Department of Urology, The Catholic University of Korea, Seoul, Korea. cyh0831@catholic. ac.kr
- Publication Type:Original Article
- Keywords:
Benign prostatic hyperplasia;
Catechin;
Testosterone;
5 alpha-reductase
- MeSH:
Aged;
Animals;
Catechin*;
Cholestenone 5 alpha-Reductase;
Eating*;
Finasteride;
Humans;
Male;
Models, Animal*;
Oxidoreductases;
Prostate;
Prostatic Hyperplasia*;
Rats*;
Rats, Wistar;
Tea;
Testosterone;
Testosterone Propionate;
Weights and Measures
- From:Korean Journal of Urology
2006;47(12):1289-1293
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Benign prostatic hyperplasia (BPH) is one of the common diseases in elderly men. Recently, the old-aged population has increased, with the interest in the clinical importance of BPH ever growing. Catechin, an extract of green tea, has the effect of the 5-alpha reductase inhibitor. Typically, BPH has been shown to be influenced by 5-alpha reductase. Therefore, the relationship between BPH and catechin was evaluated. MATERIALS AND METHODS: An experimental prostatic hyperplasia was induced in male Wistar rats by the administration of testosterone propionate, 3mg/kg sc, for 4 weeks. The Wistar rats were divided into four experimental groups: the control, BPH-induced, oral finasteride ingestion and oral catechin ingestion groups. After 4 weeks, the prostates were removed, and analyzed for their prostatic weight and histological examination. RESULTS: The prostate weights were measured in each group, and found to be 330.0+/-40.7, 970.0+/-1.1, 358.0+/-39.9 and 415.0+/-45.3mg in the control, BPH-induced, oral finasteride ingestion and oral catechin ingestion groups, respectively. The oral finasteride and catechin ingestion groups showed statistically significant decreases in their prostatic weights compared with the BPH-induced group (p<0.05), but with no significant difference between the oral finasteride and catechin ingestion groups (p>0.05). Histologically injected testosterone lead to prostatic hyperplasia in rats, but oral catechin ingestion decreased this change. CONCLUSIONS: These results suggest that catechin may be effective in BPH, and the consumption of green tea may be effective in preventing BPH.
