One-Year Mortality of Acute Kidney Injury in Patients with Acute Myocardial Infarction.
- Author:
Dae Hun LIM
1
;
Jong Hyeok JEONG
;
Ji Min JEONG
;
Chang Seong KIM
;
Joon Seok CHOI
;
Jeong Woo PARK
;
Eun Hui BAE
;
Seong Kwon MA
;
Soo Wan KIM
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. skimw@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Acute kidney failure;
Myocardial infarction;
Fatal outcome
- MeSH:
Acute Kidney Injury;
Fatal Outcome;
Hospital Mortality;
Hospitalization;
Humans;
Incidence;
Length of Stay;
Myocardial Infarction;
Renal Dialysis;
Risk Factors
- From:Korean Journal of Nephrology
2011;30(2):141-147
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Acute kidney injury (AKI) is a common complication during hospitalization and is an accepted risk factor for in-hospital mortality. However, the association of severity of AKI with the long-term risk of death is not well known. This study aimed to investigate the incidence and clinical significance of AKI in patients with acute myocardial infarction (AMI). METHODS: To examine the effect of the severity of AKI on 1-year risk of death following AMI, we performed an observational study of 1,224 patients admitted for AMI. We evaluated the association between AKI and all-cause mortality. Patients with maintaining hemodialysis treatment (n=7), and who died during hospitalization (n=71) were excluded. Remaining 1146 patients were divided into three groups according to the Acute Kidney Injury Network (AKIN) criteria (Stage-1, -2, and-3). The primary end point of the study was 1-year all-cause mortality after hospital discharge. The relation between the severity of AKI and 1-year mortality after AMI was analyzed. RESULTS: AKI was developed in 222/1,146 (19.3%) patients during the hospital stay. Adjusted hazard ratio for 1-year mortality was 3.064 (95% CI 1.618 to 5.803, p=0.001), 6.112 (95% CI 2.344 to 15.935, p<0.001) and 20.030 (95% CI 5.428 to 73.912, p<0.001) in stage-1, -2, and stage-3 AKI groups compared with that of no AKI group. CONCLUSION: The severity of AKI is strongly related to 1-year all cause mortality in patients with AMI.
