Bleeding Complications Associated With the Use of Low Molecular Weight Heparin According to the Degree of Renal Impairment.
- Author:
Eun Ju SONG
1
;
Seung Yup LEE
;
Yu Min JUNG
;
Kyung Woo NHO
;
Su Ah SUNG
;
Young Hwan HWANG
;
So Young LEE
Author Information
1. Eulji University College of Medicine, Department of Internal Medicine, Division of Nephrology, Eulji general hospital, Seoul, Korea. leesy1146@eulji.ac.kr
- Publication Type:Original Article
- Keywords:
Low molecular weight heparin;
Bleeding;
Renal insufficiency
- MeSH:
Acute Coronary Syndrome;
Cerebral Infarction;
Diabetes Mellitus;
Enoxaparin;
Glomerular Filtration Rate;
Hemorrhage;
Heparin;
Heparin, Low-Molecular-Weight;
Humans;
Hypertension;
Logistic Models;
Nadroparin;
Renal Insufficiency;
Retrospective Studies;
Smoke;
Smoking;
Venous Thromboembolism
- From:Korean Journal of Nephrology
2011;30(2):155-162
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Low molecular weight heparin (LMWH) is safe and effective in the treatment of acute coronary syndrome (ACS) and venous thromboembolism. Compared with unfractionated heparin (UFH), it is known to have less bleeding tendency in the general population. However, it is not certain whether bleeding complications are decreased by LMWH in patients with renal failure. We postulated that the use of LMWH may lead to increase in bleeding tendency in patients with renal dysfunction. METHODS: We conducted a retrospective study in 486 hospitalized patients who were diagnosed as cerebral infarction or ACS, and treated with enoxaparin or nadroparin from January 2008 to December 2009. Bleeding complications were compared in 3 groups according to estimated glomerular filtration rate (GFR> or =60, 30-59, and <30 mL/min/1.73m2). Age, hypertension (HTN), diabetes mellitus (DM), smoking and usage of antithrombotics were examined and the relationship of these variables with bleeding tendency was analyzed. RESULTS: Compared with group I, the frequency of total bleeding complications increased in patients with group II (p=0.002) and III (p=0.005) regardless of adequate dose reduction. Multiple logistic regression analysis after adjustment for age, HTN, DM, and usage of antithrombotics revealed that decreased GFR groups [odds ratio (OR) of group II was 5.79 (95% confidence interval (CI), 1.23-29.97; p=0.042), OR of group III 5.92 (95% CI, 1.22-27.61; p=0.029)] and DM [OR of DM 7.88 (95% CI; 1.46-46.32, p=0.026)] were two independent factors which affect major bleeding. CONCLUSION: These findings suggest that renal insufficiency, even if it is mild, could affect major bleeding complications in the use of LMWH.
