A Case of Cyclosporine-Induced Type I Renal Tubular Acidosis after Kidney Transplantation.
- Author:
Seung Yeon SON
1
;
Young Ki LEE
;
Hana YOO
;
Da Hye JUNG
;
Inho MOH
;
Hee Jun KIM
;
Sung Woong JUNG
;
Dong Kil NA
;
Su Chung CHANG
;
Seung Min LEE
;
Soo Jin KIM
;
Jieun OH
;
Jung Woo NOH
;
Samuel LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea. km2071@unitel.co.kr
- Publication Type:Case Report
- Keywords:
Renal tubular acidosis;
Transplantation;
Cyclosporine
- MeSH:
Acidosis;
Acidosis, Renal Tubular;
Cyclosporine;
Hypokalemia;
Kidney;
Kidney Transplantation;
Organ Transplantation;
Renal Replacement Therapy;
Seizures;
Sodium Bicarbonate;
Transplants
- From:Korean Journal of Nephrology
2011;30(2):178-182
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cyclosporine is an immunosuppressive agent that plays an important therapeutic role for organ transplantation. However, complications due to type 1 renal tubular acidosis, albeit rare, have been reported. We experienced a case of severe metabolic acidosis associated with cyclosporine administration after renal transplantation. A 54-year old man was hospitalized for seizure, confusion and weakness. He demonstrated severe metabolic acidosis and hypokalemia. Continuous renal replacement therapy was started and sodium bicarbonate was administered to correct the acidosis and the dosage of cyclosporine was reduced. Thereafter, the cyclosporine level in whole blood decreased gradually, and the metabolic acidosis improved.
