A Case of Baclofen-Induced Encephalopathy in a Patient with ESRD on Continuous Ambulatory Peritoneal Dialysis.
- Author:
Eun Hye KIM
1
;
Bun KIM
;
Su Jin LEE
;
Min Hyung KIM
;
Shin Wook KANG
;
Kyu Hyun CHIO
;
Tae Hyun YOO
Author Information
1. Department of Internal Medicine, College of Medicine, Yonsei University, seoul, Korea. Yoosy0316@yuhs.ac
- Publication Type:Case Report
- Keywords:
Baclofen;
Encephalopathy;
Continuous ambulatory peritoneal dialysis
- MeSH:
Baclofen;
gamma-Aminobutyric Acid;
Humans;
Kidney;
Kidney Failure, Chronic;
Neuroimaging;
Peritoneal Dialysis, Continuous Ambulatory;
Renal Dialysis;
Spasm;
Stupor
- From:Korean Journal of Nephrology
2011;30(2):211-214
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Baclofen (beta-4-chlorophenyl-gamma-aminobutyric acid), a gamma-aminobutyric acid (GABA) derivative, is commonly used for relief of spinal-origin spasm or pain. Baclofen is eliminated predominantly by the kidneys, putting patients with impaired renal function at particular risk for baclofen accumulation. The authors report on a case of baclofen-induced encephalopathy in a patient on continuous ambulatory peritoneal dialysis (CAPD). A 56 year old patient with ESRD on CAPD was admitted due to stuporous mental status after baclofen treatment. Brain imaging showed no specific abnormality. After intensive treatment of CAPD for 3 days, neurologic abnormality was completely recovered. Baclofen should not be recommended for patients with renal dysfunction. Although the best-known treatment choice for baclofen toxicity is hemodialysis, intensive CAPD can also be considered as an option for treatment of baclofen toxicity.
