The Decline Effect in Cardiovascular Medicine: Is the Effect of Cardiovascular Medicine and Stent on Cardiovascular Events Decline Over the Years?.
10.4070/kcj.2013.43.7.443
- Author:
Moo Sik LEE
1
;
Andreas J FLAMMER
;
Amir LERMAN
Author Information
1. Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA. Lerman.Amir@mayo.edu
- Publication Type:Review
- Keywords:
Cardiovascular drug;
Stents;
Percataneous coronary intervention
- MeSH:
Angioplasty;
Aspirin;
Bias (Epidemiology);
Peptidyl-Dipeptidase A;
Percutaneous Coronary Intervention;
Proton Pumps;
Publication Bias;
Stents
- From:Korean Circulation Journal
2013;43(7):443-452
- CountryRepublic of Korea
- Language:English
-
Abstract:
The term decline effect is referred to a diminution of scientifically discovered effects over time. Reasons for the decline effect are multifaceted and include publication bias, selective reporting, outcomes reporting bias, regression to the mean, scientific paradigm shift, overshadowing and habituation, among others. Such effects can be found in cardiovascular medicines through medications (e.g., aspirin, antithrombotics, proton pump inhibitor, beta-blockers, statins, estrogen/progestin, angiotensin converting enzyme inhibitor etc.), as well as with interventional devices (e.g., angioplasty, percutaneous coronary intervention, stents). The scientific community should understand the various dimensions of the decline effects, and effective steps should be undertaken to prevent or recognize such decline effects in cardiovascular medicines.
