Clinical Significance of p53 Gene and nm23 Gene Expression in Esophageal Cancer.
- Author:
Kuhn PARK
1
;
Jong Ho LEE
;
Young Jo SA
;
Ung JIN
;
Jong Bum KWON
;
Jae Gil PARK
;
Sun He LEE
;
Moon Sub KWAK
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Catholic University Medical College, Korea. phenix@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Esophageal neoplasms;
Oncogene proteins;
Genes, p53;
Gene expression
- MeSH:
Cell Line;
Esophageal Neoplasms*;
Esophagectomy;
Gene Expression*;
Genes, p53*;
Humans;
Korea;
Melanoma;
Oncogene Proteins;
Prognosis
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2004;37(3):261-266
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Although significant progress has been made in the surgical treatment of esophageal carcinoma as well as in the detection of early stage esophageal carcinoma by diagnostic techniques, the prognosis of the esophageal carcinoma patients remain poor. The p53 gene product is known to regulate cell growth and proliferation. And the nm23 gene was identified originally as an anti-metastatic influence whose expression was correlated inversely with tumor metastatic potential in murine melanoma cell lines. This experiment was intended to know the relationship among the p53 and nm23 gene expression versus clinicopahologic characteristics of the esophageal cancer. MATERIAL AND METHOD: Total 40 cases were collected from patients who had undergone esophagectomy at St. Mary's Hospital, Catholic university of Korea. Immunohistochemical stain for p53 mutant-type protein and nm23 proein was graded as <10% positive tumor cells: negative; 10~30% positive tumor cells: + ; 30 ~50% positive tumor cells: ++ , and >50% positive tumor cells: +++ . The tumor invasion was grades as none: - ; mild: + ; moderate: ++ ; severe: +++ . RESULT: Overexpression of p53 protein and nm23 was not associated with the survival and cliniocopathologic characteristics of the esophageal cancer. Moreover, the combination analysis of p53 and nm23 revealed that there was no relationship between the gene expression and the clinicopatholic characteristics of the esophageal cancer.
