Usefulness of Multidetector-row CT in the Evaluation of Reperfused Myocardial Infarction in a Rabbit Model.
- Author:
Jong Min PARK
1
;
Yeon Hyeon CHOE
;
Samuel CHANG
;
Yon Mi SUNG
;
Seok Seon KANG
;
Min Joo KIM
;
Boo Kyung HAN
;
Sang Hee CHOI
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Animals; Computed tomography (CT), multidetector-row; Computed tomography (CT), helical technology; Myocardium, infarction; Myocardium, CT; Heart, CT
- MeSH: Animals; Feasibility Studies; Models, Animal; Myocardial Infarction/*radiography; Myocardial Reperfusion Injury/*radiography; Rabbits; Reproducibility of Results; Support, Non-U.S. Gov't; Tomography, Spiral Computed; *Tomography, X-Ray Computed/methods
- From:Korean Journal of Radiology 2004;5(1):19-24
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To evaluate the usefulness of multidetector-row computed tomography (CT) in the evaluation of reperfused myocardial infarction. MATERIALS AND METHODS: Eleven rabbits were subjected to 90-min occlusion of the left anterior descending coronary artery followed by reperfusion. Multidetector-row CT was performed 31 hours+/-21 after the procedure and preand post-contrast multiphase helical CT images were obtained up to 10 min after contrast injection. The animals were sacrificed after 30 days and histochemical staining of the resected specimens was perfomed with 2'3'5-triphenyl tetrazolium chloride (TTC). RESULTS: In all 11 cases, the areas of myocardial infarction demonstrated with TTC-staining were identified on the CT images and the lesions showed hypoenhancement on the early phases up to 62 sec and hyperenhancement on the delayed phases of 5 min and 10 min compared with normal myocardial enhancement. The percentage area of the lesion with respect to the left ventricle wall on CT was significantly correlated with that of the TTC-staining results (p < 0.001 for both early and delayed phase CT) according to the generalized linear model analysis. The areas showing hypoenhancement on early CT were significantly smaller than those with hyperenhancement on delayed CT (p < 0.0001). CONCLUSION: Multidetector-row CT may be useful in the detection and sizing of reperfused myocardial infarction.
