Cardiopulmonary effects of thiopental versus propofol as an induction agent prior to isoflurane anesthesia in chair trained rhesus macaques (Macaca mulatta).
- Author:
Yun Jung CHOI
1
;
Hye Jin PARK
;
Hyeon Ho KIM
;
Yun Jin LEE
;
Kyeong Cheon JUNG
;
Seong Hoe PARK
;
Jae Il LEE
Author Information
- Publication Type:Original Article
- Keywords: Cardiopulmonary; thiopental; propofol; induction; rhesus monkey
- MeSH: Anesthesia*; Arterial Pressure; Blood Pressure; Carbon Dioxide; Extracellular Fluid; Heart Rate; Hydrogen-Ion Concentration; Injections, Intravenous; Isoflurane*; Lactic Acid; Macaca mulatta*; Oxygen; Partial Pressure; Propofol*; Respiratory Rate; Thiopental*
- From:Laboratory Animal Research 2016;32(1):8-15
- CountryRepublic of Korea
- Language:English
- Abstract: The purpose of this study was to evaluate the effects of thiopental versus propofol on cardiopulmonary functions, when used as an induction agent prior to isoflurane anesthesia in rhesus monkeys. Eight healthy rhesus monkeys weighing 3.72 to 5.7 kg, 4-5 years old, were used in the study. Anesthesia was induced with thiopental or propofol intravenous injection, and then maintained with isoflurane in oxygen for 45 minutes. Cardiopulmonary measurements were obtained before and 5, 15, 30, 45, and 60 minutes after induction. The induction doses of thiopental and propofol were 19.41±0.54 and 9.33±1.02 mg/kg, respectively. In both groups, the values of heart rate, respiratory rate, temperature, systolic blood pressure, mean blood pressure, diastolic blood pressure, pH, and lactate were decreased, while the values of partial pressure of carbon dioxide, partial pressure of oxygen, total carbon dioxide, bicarbonate, oxygen saturation, and base excess in the extracellular fluid were increased, as compared with baseline. Systolic blood pressure was significantly lower in thiopental group compare to propofol group. Induction time was very short in both agents but not revealed a significant difference between both groups. However, recovery time was extremely faster in the propofol group. Our results demonstrated that propofol provides a minor suppression in systolic arterial blood pressure than thiopental sodium. In addition, propofol have a fast recovery effect from the anesthesia as well. Furthermore, it is suggested that thiopental sodium could also be used to induce anesthesia instead of propofol, despite slight more suppression of cardiopulmonary function compared to thiopental sodium.
