The Bone Response to Hormone Replacement Therapy according to Basal Bone Mineral Density in Postmenopausal Women.
- Author:
Jung Gu KIM
1
;
Kwang Rai KIM
;
Byung Chul GEE
;
Seok Hyun KIM
;
Young Min CHOI
;
Shin Yong MOON
;
Jin Yong LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul 110-744, Korea.
- Publication Type:Original Article
- Keywords:
Hormone replacement therapy;
osteoporosis;
bone mineral density;
Non-responder
- MeSH:
Absorptiometry, Photon;
Bone Density*;
Bone Diseases, Metabolic;
Estrogen Replacement Therapy;
Female;
Femur Neck;
Hormone Replacement Therapy*;
Humans;
Incidence;
Osteoporosis;
Spine
- From:Korean Journal of Obstetrics and Gynecology
2001;44(8):1450-1454
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the incidence of non-responder to hormone replacement therapy (HRT) and to evaluate the bone response to HRT according to basal bone mineral density(BMD) in postmenopausal women. METHODS: A total of 211 postmenopausal women received either continuous combined estrogen-progestogen replacement (n=112) or estrogen replacement (n=99) for 1 years. BMD at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry (DEXA) before and 1 year after HRT. RESULTS: The incidence of non-responder (women with > 3% bone loss per year) to HRT was 9.2% in the lumbar spine, and 23.8% in femoral neck. Estrogen replacement group had a higher incidence of non-responder than combined replacement group. Non-responder group had a higher basal BMD at the lumbar spine than responder group, and showed bone loss rate of 7.6% per year. After 1 year of HRT, postmenopausal women with osteoporosis showed a higher rate of increase in BMD at the lumbar sine and femoral neck than women with normal BMD or osteopenia. CONCLUSION: The non-responders to HRT have a higher basal lumbar BMD, compared with responders. The higher basal BMD at the lumbar spine is, the less bone conservation effect of HRT is.
