Effects of cetirizine in dogs with chronic atopic dermatitis: a randomized, double blind, placebo-controlled trial.
10.4142/jvs.2016.17.4.549
- Author:
Yun Hsia HSIAO
1
;
Charles CHEN
;
Ton WILLEMSE
Author Information
1. Asian Referral Center, Taipei 106, Taiwan. hsiao.derm@gmail.com
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
atopic dermatitis;
cetirizine;
dogs;
placebo-controlled study
- MeSH:
Animals;
Cetirizine*;
Dermatitis, Atopic*;
Dogs*;
Hypersensitivity;
Pruritus;
Receptors, Histamine;
Visual Analog Scale
- From:Journal of Veterinary Science
2016;17(4):549-554
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was conducted to evaluate the effects of cetirizine in dogs with atopic dermatitis (AD) while fulfilling Favrot's diagnostic clinical criteria. Dogs received either 3 mg/kg cetirizine (n = 27), or a placebo (n = 23) orally once daily for 14 days in a randomized, double blind, placebo-controlled study, without concomitant medication. The effects were evaluated using a pruritus visual analog scale at the start (day 0) and at day 14. After 14 days, cetirizine clearly had no effect on the pruritus in dogs with chronic AD, and there was no significant difference between groups. These findings indicated that cetirizine (and likely H1 histamine receptor antagonists in general) should not be recommended for the control of pruritus in dogs with long term allergies.
