Hepatocellular Carcinoma Following Vertical Transmission of Hepatitis B Virus in a Child with X-linked Agammaglobulinemia.
- Author:
Jong Gon OH
1
;
Byung Ju KIM
;
Hoon KOOK
;
Young Jong WOO
;
Young Youn CHOI
;
Jae Sook MA
;
Tai Ju HWANG
;
Jong Jin SEO
Author Information
1. Department of Pediatrics, St. Columban's Hospital, Mokpo, Korea.
- Publication Type:Case Report
- Keywords:
X-linked agammaglobulinemia;
Hepatocellular carcinoma;
Child;
Hepatitis B
- MeSH:
Adolescent;
Agammaglobulinemia*;
B-Lymphocytes;
Carcinoma, Hepatocellular*;
Child*;
Hepatitis B virus*;
Hepatitis B*;
Hepatitis*;
Humans;
Male;
Prevalence
- From:Korean Journal of Pediatric Gastroenterology and Nutrition
2000;3(1):105-109
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
X-linked agammaglobulinemia (XLA) is a primary inherited B-cell immunodeficiency. The prevalence of neoplastic disease in patients with XLA is approximatedly 0.7%. The most frequent tumor is lymphoreticular malignancy. We report a case of hepatocellular carcinoma (HCC) in a 13-year-old boy with XLA, after probable maternal transmission of hepatitis B virus. The authors consider that the vertical transmission of hepatitis B virus might play an important role in the development of HCC in a child with XLA who could not eliminate hepatitis B virus effectively.
