Seasonal Influenza-Related Neurologic Complications in Children from 2010 to 2015.
- Author:
Hui Jeong YUN
1
;
Myoung Soo NAM
;
Yong Wook KIM
;
Kyoung Sim KIM
;
Hyung Min CHO
;
Young KIM
;
Eun Young KIM
Author Information
1. Department of Pediatrics, Kwangju Christian Hospital, Gwangju, Korea. eykim_kook@yahoo.com
- Publication Type:Original Article
- Keywords:
Influenza A virus;
Influenza B virus;
Seizues;
Febrile;
Child;
Risk Factors
- MeSH:
Child*;
Diagnosis;
Encephalitis;
Guillain-Barre Syndrome;
Gwangju;
Humans;
Incidence;
Influenza A virus;
Influenza B virus;
Influenza Vaccines;
Influenza, Human;
Meningitis, Aseptic;
Prognosis;
Retrospective Studies;
Risk Factors;
Seasons*;
Seizures;
Seizures, Febrile
- From:
Journal of the Korean Child Neurology Society
2017;25(2):93-98
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Influenza-associated neurologic complications in children are diverse. But there has been little long-term and large-scale research about neurologic complications of seasonal influenza. This study aimed to identify the incidence, characteristics, and risk factors for neurologic complications in children hospitalized with influenza. METHODS: Retrospective analysis was conducted on the clinical data of 940 children hospitalized with confirmed influenza infection from Oct, 2010 to May, 2016 in Kwangju Christian Hospital. RESULTS: A total of 940 children with influenza were hospitalized, of whom 96 (10.2%) had neurologic complications:81 children presented febrile seizures (8.6%) and some included 12 other seizures (1.3%),1 encephalitis (0.1%), 1 Guillain-Barré syndrome (0.1%), 1 aseptic meningitis (0.1%). They had good prognosis except the encephalitis child. The incidence of neurologic complications was significantly higher in influenza A than in influenza B (11.9% vs. 7.0%, P=0.036). The incidence of influenza A was highest in February, while that of influenza B was highest in March and April. The monthly distribution of neurological complications reflected the influenza incidence. The risk factors for influenza-associated neurologic complications were underlying neurologic disease and young age. No significant clinical differences were observed between influenza A and B in febrile seizure. CONCLUSION: Febrile seizures are the most common neurologic complication with good prognosis. Although encephalitis/encephalopathy is rare, it can be severe with sequelae, so prompt diagnosis and treatment should be initiated. And influenza vaccine should be encouraged to children with underlying neurologic disease.
