Association of Hyperhomocysteinemia and MTHFR Genotype in Parkinson's Disease.
- Author:
Jun Hyun YOO
1
;
Won Young LEE
Author Information
1. Department of Family Medicine, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea. drjohn.yoo@samsung.com
- Publication Type:In Vitro ; Original Article
- Keywords:
Methylenetetrahydrofolate reductase;
Parkinson's disease;
Homocysteine
- MeSH:
Animal Experimentation;
Dopaminergic Neurons;
Genotype*;
Homocysteine;
Humans;
Hyperhomocysteinemia*;
Methylenetetrahydrofolate Reductase (NADPH2);
Parkinson Disease*
- From:Journal of the Korean Geriatrics Society
2006;10(3):172-176
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) deficiency is rare in severe cases but common in mild cases. TT genotype of C677T of MTHFR shows reduced enzyme activity and hyperhomocysteinemia. It has been shown that homocysteine is very toxic to dopaminergic neuronal cell in vitro and animal experiment, which suggests some role of homocysteine in the pathogenesis of Parkinson's disease (PD). This study examined the association of MTHFR genotype, hyperhomocysteinemia, and Parkinson's disease. METHODS: Serum homocysteine concentration and the C677T genotypes of MTHFR were assessed in 80 patients with Parkinson's disease, and 80 healthy subjects matched for age and gender, in a hospital-based setting. RESULTS: Proportion of moderate hyperhomocysteinemia (plasma homocyst(e)ine > or =15 micromol/L) was higher in patients with Parkinson's disease than in normal controls (53.7% vs 30.0%, p=0.01). TT genotype of MTHFR was highly frequent in Parkinson's disease patients compared to controls (18.7% vs 11.3%, p=0.01). The combination of hyperhomocysteinemia and TT genotype of MTHFR augmented risk for Parkinson's disease (odds ratio 2.53 [95% confidence interval, 1.48-4.31, p=0.01]). CONCLUSIONS: Hyperhomocysteinemia is a common finding in the patients with Parkinson's disease. TT genotype of MTHFR is at increased risk for Parkinson's disease, and in conjunction with hyperhomocyeteinemia, augments the association.
