Effect of ApoE Genotype on the Relationship between Nutritional Risk and Cognition in the Elderly.
- Author:
Chang Hyung HONG
1
;
Hae Kwan CHEONG
;
Eun A KIM
;
Kang Soo LEE
;
Kyung Ran KIM
;
Kyung Ryeol CHA
;
Ji Hey CHOI
;
Byoung Hoon OH
Author Information
1. Department of Psychiatry, College of Medicine, Yonsei University College of Medicine, Korea. drobh@chollian.net
- Publication Type:Original Article
- Keywords:
Nutrition;
NSI checklist;
K-MMSE;
Elderly;
ApoE genotyping
- MeSH:
Aged*;
Alleles;
Apolipoproteins E*;
Blood Glucose;
Blood Pressure;
Body Mass Index;
Checklist;
Cognition*;
Dementia;
Depression;
Fasting;
Genotype*;
Humans;
Logistic Models;
Male;
Mass Screening;
Surveys and Questionnaires
- From:Journal of the Korean Geriatrics Society
2006;10(3):177-185
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The purpose of this study is to find out the effect of ApoE genotype on the relationship between nutritional risk and cognition of the elderly in a community. METHODS: A total of 996 subjects (343 men and 653 women) aged 60~91 years were analyzed from preliminary data of GDEMCIS (Gwangju Dementia and MCI Study). The study questionnaire consisted of demographic characteristics, current and past illness history, drug history, K-SGDS (Korean version of Short Form Geriatric Depression Scale), K-MMSE (Korean version-Mini Mental State Examina- tion), and NSI (Nutritional Screening Initiative) checklist. We also examined blood pressure, fasting serum glucose, lipid profile, body mass index, and ApoE genotyping. RESULTS: 649 subjects (65.2%) were on good nutritional state (NSI score < or = 2) and 347 subjects (34.8%) were on moderate or high nutritional risk (NSI score > or = 3). On multiple logistic regression analysis, moderate or high nutritional risk was associated with an increa- sed risk for cognitive impairment (K-MMSE score < or = 17) after adjustment with age, sex, K-GDS and educational level in the absence of ApoE epsilon4 allele (OR 1.78, 95% CI 1.15-2.77). CONCLUSION: These results suggest that nutritional risk may be associated with cognitive function in the elderly only in the absence of ApoE epsilon4 allele.
