Two Cases of Acute Poststreptococcal Glomerulonephritis Superimposing to IgA Nephropathy.
- Author:
Young Kyoun KIM
1
;
Jun Ho LEE
;
Hyewon HAHN
;
Il Soo HA
;
Hae Il CHEONG
;
Yong CHOI
Author Information
1. Department of Pediatrics, College of Medicine, Inje University, Seoul Paik Hospital, Korea. kik4pedi@hanmail.net
- Publication Type:Case Report
- Keywords:
Acute poststreptococcal glomerulonephritis;
IgA Nephropathy;
Superimposing
- MeSH:
Biopsy;
Child;
Complement System Proteins;
Edema;
Glomerulonephritis*;
Glomerulonephritis, IGA*;
Hand;
Hematuria;
Humans;
Immunoglobulin A*;
Proteinuria
- From:Journal of the Korean Society of Pediatric Nephrology
2000;4(2):154-160
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The pathogenesis of IgA nephropathy and acute poststreptococcal glomerulonephritis is not fully understood. In the past, acute poststreptococcal glomerulonephritis was the most common cause of gross hematuria in children, but now IgA nephropathy is the most common one. We experienced two cases of acute poststreptococcal glomerulonephritis superimposing to IgA nephropathy in boys. Case 1 had upper respiratory infection before elevation of anti-streptolysin O, generalized edema, gross hematuria and proteinuria. The complement levels were normal. Electron microscopic findings of renal biopsy at ten days after onset showed a few big subepithelial 'humps' and localized heavy subendothelial and mesangial deposits. Immunofluoroscopic findings revealed predominant IgA deposition in the mesangium. The electron microscopic findings were diagnostic of acute poststreptococcal glomerulonephritis. On the other hand, immunoflorescence microscopic findings were compatible to IgA nephropathy. In case 2, the renal biopsy which was done 2 years after onset showed only finding of IgA nephropathy. To our knowledges, there has been few reports of acute poststreptococcal glomerulonephritis superimposing to IgA nephropathy which was confirmed by renal biopsy. We report two cases of acute poststreptococcal glomerulonephritis superimposing to IgA nephropathy with a brief review of the literatures.
