The Effectiveness of Gefitinib on Spinal Metastases of Lung Cancer: Report of Two Cases.
- Author:
Mineyuki ZUKAWA
1
;
Masato NAKANO
;
Norikazu HIRANO
;
Keiichi MIZUHASHI
;
Masahiko KANAMORI
Author Information
- Publication Type:Case Report
- Keywords: Gefitinib; Bone metastases; Lung cancer
- MeSH: Cell Proliferation; Humans; Lung; Lung Neoplasms; Neoplasm Metastasis; Osteogenesis; Quinazolines
- From:Asian Spine Journal 2008;2(2):109-113
- CountryRepublic of Korea
- Language:English
- Abstract: Lung cancer has a high mortality rate and is often diagnosed at the metastatic stage. Recently, gefitinib, a molecule target therapeutic drug, has offered a new approach for patients with non-small-cell lung cancer (NSCLC). This report describes the effects of gefitinib on bone metastases in two patients with NSCLC. The pain induced by a bone metastasis was relieved after the administration of gefitinib. Furthermore, the radiographs and CT findings showed sclerotic changes that matched those of the metastatic bone tumor after gefitinib administration in both patients. It is believed that gefitinib inhibited tumor cell proliferation and induced normal bone formation. In patients with NSCLC, gefitinib may be effective in the treatment of bone metastases.
