A Case of Lichenoid Drug Eruption Caused by Antituberculosis Drug.
10.12701/yujm.1995.12.2.405
- Author:
Soo Keoung LEE
;
Jong Soo CHOI
;
Ki Hong KIM
- Publication Type:Case Report
- Keywords:
Lichenoid drug eruption;
Autituberculosis drug
- MeSH:
Aged;
Alopecia;
Dermis;
Drug Eruptions*;
Ethambutol;
Extremities;
Female;
Humans;
Hyperpigmentation;
Lichen Planus;
Skin
- From:Yeungnam University Journal of Medicine
1995;12(2):405-411
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Lichenoid drug eruption is lichenoid skin eruptions caused by certain drugs and compounds, and can be identical or similiar to lichen planus. A 75-year-old woman who had taken antituberculosis medication(INH, ethambutol, rifampin) for 4 months developed pruritic generalized erythematous papular eruptions on the trunk and extremities, alopecia and nail dystropy. Histopathologic findings were hyperkeratosis, hypergranulosis, hyc rophic degenaration of basal layer, band like lymphohistiocytic infiltration in the upper dermis and perivascular lymphohistiocytic infiltration in the deep dermis. She was treated with systemic corticosteroid, and then skin lesion were slightly improved. After termination of antituberculosis medication, skin lesions were markedly improved with residual hyperpigmentation. Alopecia and nail dystrophy were also improved.
