Clinicopathologic Studies of 7 Cases with Cutaneous Metastatic Carcinomas from Lung Cancers.
- Author:
Sang Won JEONG
1
;
Sang Won LEE
;
Jae Hoon CHUN
;
Seung Hoon CHA
;
Eun Taek JEONG
;
Seok Don PARK
Author Information
1. Department of Dermatology, Wonkwang University School of Medicine, Iksan, Korea.
- Publication Type:Original Article
- Keywords:
Lung cancer;
Skin metastasis
- MeSH:
Antigens, CD45;
Carcinoma, Squamous Cell;
Diagnosis;
Humans;
Keratins;
Lung Neoplasms*;
Lung*;
Male;
Mucin-1;
Neck;
Neoplasm Metastasis;
Paraffin;
Phosphopyruvate Hydratase;
Prognosis;
Scalp;
Skin;
Skin Neoplasms;
Survival Rate;
Thorax
- From:Korean Journal of Dermatology
1999;37(11):1576-1582
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cancer that tends to metastasize to other internal organs also involves the skin with various clinical features. OBJECTIVE: We studied the clinical and histopathological findings of metastatic skin cancer and primary lung cancer. METHODS: We reviewed the clinical features and histopathological findings in 7 patients with metastatic skin cancer from the lung cancer. We performed routine hematoxylin-eosin stain and immunohistochemical staining with monoclonal antibody to cytokeratin, neuron specific enolase, S-100, leukocyte common antigen, and epithelial membrane antigen using the formalin-fixed paraffin embedded skin tissue of cutaneous metastatic and primary lung cancer. RESULTS: All patients are men ranging from 44 to 72 years in age(mean, 63.0 years). Cutaneous lesions were nodule, tumor, and sclerotic plaque. Skin lesions appeared on all parts of body. The neck, chest, and scalp were the most common locations of metastases. Pathologic findings were squamous cell carcinoma in 5 patients, adenosquamous cell carcinoma in 2 patients. We found some different immunophenotypes in cutaneous metastatic lesion and lung cancer. Mean survival time from the diagnosis of lung cancer was 10.4 months, and 8.4 months from the diagnosis of skin metastasis. CONCLUSION: We conclude that patients with cutaneous metastasis of lung cancer reflect progressive, terminal stage, and poor prognosis of the disease.
