Clinical and Histopathological Study of Cellulitis.
- Author:
Gwang Bum AHN
1
;
Seung Ho CHANG
;
Tae Young YOON
Author Information
1. Department of Dermatology, College of Medicine, Chungbuk National University, Cheongju, Korea.
- Publication Type:Original Article
- Keywords:
Cellulitis;
Escherichia coli;
Brown-Brenn staining;
Gram staining
- MeSH:
Adult;
Anti-Bacterial Agents;
Arthritis, Infectious;
Blister;
Bursitis;
Cellulitis*;
Chungcheongbuk-do;
Dermatology;
Dermis;
Diabetes Mellitus;
Erythema;
Escherichia coli;
Female;
Heating;
Herpes Zoster;
Hot Temperature;
Humans;
Inflammation;
Insect Bites and Stings;
Korea;
Lower Extremity;
Male;
Medical Records;
Neutrophils;
Orthopedics;
Osteomyelitis;
Recurrence;
Sex Ratio;
Subcutaneous Fat;
Subcutaneous Tissue;
Tinea Pedis;
Vasculitis
- From:Korean Journal of Dermatology
1999;37(11):1617-1626
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cellulitis is a suppurative inflammation involving particularly the subcutaneous tissue. There has been no data about its clinicopathologic features in Korea. OBJECTIVES: The purpose of this study was to investigate the clinicopathologic characteristics of cellulitis and to assess the yield rate of special stainings (Brown-Brenn, Gram) for organisms. METHODS: We reviewed the medical records and histologic sections of 45 patients who had been diagnosed as cellulitis in the Department of Dermatology, Chungbuk National University Hospital from January 1992 to August 1998. RESULTS: The results were as follows. 1. The sex ratio of male to female was 1.5:1 and average age was 43 years old. 2. The lower extremity was the most frequently involved site of cellulitis with a frequency of 53.4%. 3. Erythema, tenderness, local heating, swelling, and pain were almost always presenting clinical manifestations. 4. Diabetes mellitus was the most frequent underlying systemic disease. 5. The route of infection was suspected in 25 cases(55.6%). Tinea pedis was strongly suspected in 7 cases(28.0%), and followed by insect bite in 5 cases(20.0%), herpes zoster in 4 cases(16.0%), and trauma in 2 cases(8.0%). 6. The main complications were orthopedic problems including bursitis, osteomyelitis, and septic arthritis. 7. Microorganisms were isolated in 20 of 43 tissue cultures(46.5%). 8. It is important to suspect Escherichia coli as a causative organism if blistering cellulitis occurs, especially in patients with underlying systemic disease. 9. The most frequent histopathologic findings were perivascular lymphohistiocytic infiltrations in both dermis and subcutaneous fat simultaneously without vasculitis. 10. Special stainings(Brown-Brenn or Gram) were worthy to try, especially in the neutrophilic dominant cellulitis. 11. First-generation cephalosporin was chosen as primary antibiotics in 31 cases, and there was no difference in clinical course between its monotherapy and combined therapy. 12. Twenty percent of cases experienced recurrences. Lower extremity was most common site of recurrence(63.6%). CONCLUSION: Diabetes mellitus and tinea pedis were so closely bound up with cellulitis that control of those diseases is important in view of the clinical course of cellulitis. Special stainings(Brown-Brenn or Gram) were worthy to try, especially in the neutrophilic dominant cellulitis.
