Neonatal Lupus Erythematosus.
- Author:
Deok Yong SHIN
1
;
Sang Mee SEOK
;
Dae Won KOO
Author Information
1. Department of Dermatology, College of Medicine, Hallym University Chunchon, Korea.
- Publication Type:Case Report
- Keywords:
Neonatal lupus erythematosus;
Anti-SSA/Ro antibody
- MeSH:
Anemia;
Antibodies;
Antibodies, Antinuclear;
Arthralgia;
Extremities;
Heart Block;
Humans;
Infant;
Infant, Newborn;
Leukopenia;
Lupus Erythematosus, Systemic;
Mothers
- From:Korean Journal of Dermatology
1999;37(11):1649-1654
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neonatal lupus erythematosus (NLE) is a transplacentally acquired autoimmune disorder, which is characterized by cutaneous lesions and/or congenital heart block and less commonly hepatic and hematologic abnormalities. Affected infants acquire anti-SSA/Ro antibody, anti-SSB/La antibody or less commonly anti-U1RNP antibody transplacentally from maternal circulation and it is generally thought that these antibodies are pathogenic. We report a case of NLE in a 40-day-old neonate who had erythematous annular patches on his face and extremities. Serological studies were reactive for antinuclear antibody of the speckled pattern and positive for anti-SSA/Ro antibodies and anti-SSB/La antibodies in both mother and infant. Addition to these findings, his mother had complained photosensitivity and arthralgia and showed hematological abnormalities including anemia and leukopenia, so we diagnosed his mother as systemic lupus erythematosus.
