Nomograms Predicting Platinum Sensitivity, Progression-Free Survival, and Overall Survival Using Pretreatment Complete Blood Cell Counts in Epithelial Ovarian Cancer.
- Author:
E Sun PAIK
1
;
Insuk SOHN
;
Sun Young BAEK
;
Minhee SHIM
;
Hyun Jin CHOI
;
Tae Joong KIM
;
Chel Hun CHOI
;
Jeong Won LEE
;
Byoung Gie KIM
;
Yoo Young LEE
;
Duk Soo BAE
Author Information
- Publication Type:Original Article
- Keywords: Nomograms; Prognosis; Ovarian neoplasms
- MeSH: Blood Cell Count*; Blood Cells*; Disease-Free Survival*; Drug Therapy; Humans; Leukocytes; Lymphocytes; Monocytes; Multivariate Analysis; Neutrophils; Nomograms*; Ovarian Neoplasms*; Platelet Count; Platinum*; Prognosis; Retrospective Studies
- From:Cancer Research and Treatment 2017;49(3):635-642
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: This study was conducted to evaluate the prognostic significance of pre-treatment complete blood cell count (CBC), including white blood cell (WBC) differential, in epithelial ovarian cancer (EOC) patients with primary debulking surgery (PDS) and to develop nomograms for platinum sensitivity, progression-free survival (PFS), and overall survival (OS). MATERIALS AND METHODS: We retrospectively reviewed the records of 757 patients with EOC whose primary treatment consisted of surgical debulking and chemotherapy at Samsung Medical Center from 2002 to 2012. We subsequently created nomograms for platinum sensitivity, 3-year PFS, and 5-year OS as prediction models for prognostic variables including age, stage, grade, cancer antigen 125 level, residual disease after PDS, and pre-treatment WBC differential counts. The models were then validated by 10-fold cross-validation (CV). RESULTS: In addition to stage and residual disease after PDS, which are known predictors, lymphocyte and monocyte count were found to be significant prognostic factors for platinum-sensitivity, platelet count for PFS, and neutrophil count for OS on multivariate analysis. The area under the curves of platinum sensitivity, 3-year PFS, and 5-year OS calculated by the 10-fold CV procedure were 0.7405, 0.8159, and 0.815, respectively. CONCLUSION: Prognostic factors including pre-treatment CBC were used to develop nomograms for platinum sensitivity, 3-year PFS, and 5-year OS of patients with EOC. These nomograms can be used to better estimate individual outcomes.
