Adjuvant Chemotherapy after Surgical Resection for Small-Cell Carcinoma of Lung.
10.4046/trd.2004.57.5.443
- Author:
Hak Ryul KIM
1
;
Jong Hoon JUNG
;
Hwi Jung KIM
;
Sei Hoon YANG
;
Eun Taik JEONG
Author Information
1. Department of Internal Medicine, College of Medicine, Wonkwang University, Iksan, Korea. jetpul@wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Small-cell lung carcinoma;
Operation;
Chemotherapy;
Survival
- MeSH:
Autopsy;
Chemotherapy, Adjuvant*;
Drug Therapy;
Drug Therapy, Combination;
Humans;
Lung*;
Neoplasm Metastasis;
Radiotherapy;
Recurrence;
Retrospective Studies;
Survival Rate
- From:Tuberculosis and Respiratory Diseases
2004;57(5):443-448
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Small-cell carcinoma of lung has a tendency of rapid growth and early wide metastasis. In spite of high response rate of combination chemotherapy alone or with radiotherapy, overall long-term survival rate is very disappointed. According to autopsy findings, the common cause of failure is local recurrence in primary cancer site. So, surgical resection with combined chemotherapy has been recently attempted for very early stage of small-cell carcinoma of lung. METHODS: 10 patients (TNM I: & II: 5 cases) undergoing surgical resection for small-cell carcinoma of lung with adjuvant chemotherapy in an attempt to prolong survival. Of these, 9 patients received chemotherapy, and retrospective study was undertaken for survival (Kaplan-Meier analysis). RESULTS: Median survival time was 26 months, 2-, 5-year survival rate was 68.6%, 46.7%. If 1 patient without chemotherapy was excluded, 2-, 5-year survival rate was 76.2%, 50.8%. No survival difference was seen between patients with TNM I, II stages. CONCLUSION: Adjuvant chemotherapy after surgical resection results in prolonged survival for patients with TNM stage I, II small-cell carcinoma of lung.
