Therapy-related myeloid neoplasms in children and adolescents.
- Author:
Hee Won CHO
1
;
Young Bae CHOI
;
Eun Sang YI
;
Ji Won LEE
;
Ki Woong SUNG
;
Hong Hoe KOO
;
Keon Hee YOO
Author Information
- Publication Type:Original Article
- Keywords: Therapy-related myeloid neoplasms; Pediatric population; Allogeneic hematopoietic stem cell transplantation
- MeSH: Adolescent*; Child*; Chromosome Aberrations; Diagnosis; Disease-Free Survival; Humans; Latency Period (Psychology); Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Medical Records; Myelodysplastic Syndromes; Parents; Retrospective Studies; Transplantation, Homologous
- From:Blood Research 2016;51(4):242-248
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: This retrospective study aimed to characterize and analyze the outcome of therapy-related myeloid neoplasms (t-MNs) in children and adolescents. METHODS: The medical records of 16 patients under 21 years of age at the time of t-MN diagnosis were reviewed. RESULTS: The median patient age was 11.5 years (range, 1.6–20.4 yr). Twelve patients had therapy-related acute myeloid leukemia, 3 patients had myelodysplastic syndrome, and 1 patient had chronic myelomonocytic leukemia. The median latency period was 29 months (range, 11–68 mo). Fourteen patients had cytogenetic aberrations, 8 of whom had an 11q23 abnormality. Of the 13 patients treated with curative intent, 12 patients received myeloid-type induction therapy that led to complete remission (CR) in 8 patients. Nine patients underwent allogeneic transplantation; 4 patients did not undergo transplantation due to chemotherapy-related toxic death (N=3) or parental refusal (N=1). The 5-year overall survival and event-free survival of the 13 patients treated with a curative intent were 46.2% and 30.8%, respectively. For the 9 patients who underwent allogeneic transplantation, the 5-year event-free survival was 66.7%. CONCLUSION: A significant proportion of young patients with t-MNs can experience long-term survival, and allogeneic transplantation plays a key role for attaining cure in these patients.
