Significance of Susceptible Gene Expression Profiles in Nasal Polyposis.
- Author:
De Yun WANG
1
Author Information
1. Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. entwdy@nus.edu.sg
- Publication Type:Review
- Keywords:
Nasal polyposis;
Genetics;
Gene expression profile;
Pathogenesis and pathophysiology;
Susceptible genes and pathways
- MeSH:
Achievement;
Biology;
Gene Expression;
Genetic Association Studies;
Mucous Membrane;
Transcriptome
- From:Clinical and Experimental Otorhinolaryngology
2008;1(4):177-183
- CountryRepublic of Korea
- Language:English
-
Abstract:
Nasal polyposis (NP) is a common chronic inflammatory disease of the rhinosinus mucosa and a complex disease with strong genetic and environmental components. During the past 10 to 20 yr, many studies have been performed to determine differential gene expression profiles between NP and normal nasal tissues, in order to identify susceptible genes that are associated with NP-related traits. Despite achievement in the identification of candidate genes and their associated pathogenic pathways, the large challenges remain as the genetic and molecular alterations required for its development and progression are still unclear. Therefore, the development of novel, powerful tools for gene discovery, and a closer integration of genetics and medical biology would provide valuable insight into the pathogenesis of NP.
