Concentration of Tobramycin in the Cornea and Sclera After Subconjunctival Injection of Negatively-charged Liposome Encapsulated Tobramycin in Rabbits.
- Author:
Seung Han HAN
1
;
Eung Kweon KIM
;
Hong Bok KIM
;
Hyung Lae KIM
Author Information
1. Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Bacterial keratitis;
Liposome-encapsulated tobramycin;
subconjunctival injection
- MeSH:
Bacteria;
Cornea*;
Keratitis;
Liposomes*;
Ophthalmic Solutions;
Rabbits*;
Sclera*;
Tobramycin*;
Ulcer
- From:Journal of the Korean Ophthalmological Society
1989;30(1):17-22
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Bacterial keratitis is a common ophthalmic disease. Recently, topical and subconjunctival therapy were equally effective in reducing the number of viable bacteria in experimental corneal ulcers. Subconjunctival injection produced high but transient concentrations followed by persistent low levels. In contrast, eyedrops produced moderate but sustained concentrations throughout the treatment period. Liposomes are small, biodegradable lipid vesicles with an aqueous core. Incorporation of drugs into liposomes provides a convenient way to retard their release from a relatively inert depot without changing the intrinsic characteristics of the agents.
