Topical Autologous Fibronectin in the Treatment of Persistent Corneal Epithelial defects.
- Author:
Ki San KIM
1
;
Moon Jin NAM
;
Joon Sup OH
;
Rang Woon PARK
;
In San KIM
;
Joon Seung JO
Author Information
1. Department of Ophthalmology, Keimyung University, School of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
fibronectin;
persistent corneal epithelial defect
- MeSH:
Extracellular Matrix;
Fibronectins*;
Follow-Up Studies;
Glycoproteins;
Humans;
Ophthalmic Solutions;
Plasma;
Recurrence
- From:Journal of the Korean Ophthalmological Society
1989;30(1):29-36
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Fibronectin, a glycoprotein, is present in plasma and extracellular matrix and is responsible for cellular adhesion. Fibronectin was purified from autologous plasma of two persistent corneal epithelial defect patients by affinity chromatogaphy and administered topically 500 micro ml, 2 dropsper time, five times a day for 3 weeks. Reepithelization began three to seven days after initiation of treatment with autologous purified fibronectin eyedrops, and epithelial defects healed nearly completely and subjective symptoms were relieved. No side effects were observed. Over a follow-up period of 4 to 23 wks, no recurrences were noted.
