Novel swine-origin H1N1 influenza.
10.3345/kjp.2009.52.8.862
- Author:
Jina LEE
1
;
Hoan Jong LEE
Author Information
1. Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea. hoanlee@snu.ac.kr
- Publication Type:Review
- Keywords:
Novel swine-origin H1N1 influenza;
S-OIV;
Pandemic;
Vaccine
- MeSH:
Diarrhea;
Disease Outbreaks;
Humans;
Influenza A virus;
Influenza A Virus, H1N1 Subtype;
Influenza, Human;
Neuraminidase;
Pandemics;
Sprains and Strains;
Swine;
Vomiting
- From:Korean Journal of Pediatrics
2009;52(8):862-868
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Since its identification in April 2009, a swine-origin H1N1 influenza A virus (S-OIV) which is a reassortment of gene segments from both North American triple-reassortant and Eurasian swine influenza has been widely spread among humans in unexpected rapidity. To date, each gene segment of the 2009 influenza A (H1N1) outbreak viruses have shown high (99.9%) neucleotide sequence identity. As of July 6, 94,512 people have been infected in 122 countries, of whom 429 have died with an overall case-fatality rate of <0.5%. Most confirmed cases of S-OIV infection have been characterized by self-limited, uncomplicated febrile respiratory illness and 38% of cases have also included vomiting or diarrhea. Standard plus droplet precautions should be adhered to at all times. Tests on S-OIV have indicated that current new H1N1 viruses are sensitive to neuraminidase inhibitors (oseltamivir). However, current less virulent S-OIV may evolve into a pathogenic strain or acquire antiviral resistance, potentially with more severe clinical consequences. Efforts to control these outbreaks would be based on our understanding of novel S-OIV and previous influenza pandemics.
