A Case of Focal Segmental Glomerulosclerosis in Takayasu's Arteritis.
- Author:
Sin Myung KANG
1
;
Young Su SONG
;
Joo Seung KIM
;
Soo Young YOON
;
Roo Tha LEE
;
Gyu Hun CHOI
;
Seung Yeon CHO
;
Ho Yung LEE
;
Dae Suk HAN
;
Hyeon Joo JEONG
Author Information
1. Department of Internal Medicine, Institute of Kidney Disease, Korea.
- Publication Type:Case Report
- Keywords:
Takayasu's arteritis;
Focal segmental glomerulosclerosis
- MeSH:
Angiography;
Aorta, Thoracic;
Arteries;
Biopsy;
Cholesterol;
Creatinine;
Extremities;
Glomerulonephritis;
Glomerulosclerosis, Focal Segmental*;
Hematuria;
Humans;
Hypertension, Renovascular;
Lower Extremity;
Prednisolone;
Proteinuria;
Takayasu Arteritis*
- From:Korean Journal of Nephrology
2000;19(5):959-964
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Takayasu's arteritis(TA) is a chronic inflammatory and obliterative disease of medium- and large-sized arteries characterized by a strong predilection for the aortic arch and its branches. Renal involvement is usually manifested by renovascular hypertension. Glomerular involvement is rare and largely exists as a mild mesangial proliferative glomerulonephritis, commonly manifesting microscopic hematuria and proteinuria. The association of glomerular disease with TA is of interest since common immunologic mechanisms are proposed for the pathogenesis of both entities. We report a case of TA associated with focal segmental glomerulosclerosis. The patient presented with hypertension(Upper limb; Rt. 200/80mmHg, Lt. 95/60mmHg, Lower limb; Rt. 140/90mmHg, Lt. 110/70mmHg) and nephrotic syndrome(Serum albumin : 2.3g/dL, cholesterol : 454mg/dL, BUN : 18.0mg/dL, creatinine 1.3mg/dL, 24-hour urine protein : 5.17g). Digital substraction angiography showed multiple narrowing and occlusive changes of aortic arch and its branches. Renal biopsy was interpreted as focal segmental glomerulosclerosis. Therapy was instituted with prednisolone.
