Expressions and Diagnostic Usefulness of MIB-1 and p53 in Uterine Smooth Muscle Tumors.
- Author:
Mi Jin KIM
1
;
Yong Jin KIM
;
Seung Ho LEESEUNGHO
Author Information
1. Departments of Pathology and Obstetrics and Gynecology, Yeungnam University, College of Medicine, Daegu 705-035, Korea. mjkap@med.yu.ac.kr
- Publication Type:Original Article
- Keywords:
Uterine neoplasms;
Smooth muscle tumor;
Protein p53;
Ki-67 antigen;
Immunohistochemistry
- MeSH:
Classification;
Immunohistochemistry;
Ki-67 Antigen;
Leiomyoma;
Leiomyomatosis;
Leiomyosarcoma;
Muscle, Smooth*;
Smooth Muscle Tumor*;
Uterine Neoplasms
- From:Korean Journal of Pathology
2001;35(6):524-530
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Controversy still remains concerning the criteria for the categorization of uterine smooth muscle tumors by conventional histologic examination. Various ancillary techniques have been used to improve diagnostic accuracy. METHODS: Immunohistochemical study of MIB-1 and p53 was performed on 10 usual leiomyomas (UL), 13 cellular leiomyomas (CL), 5 bizarre leiomyomas (BL), 2 cases of intravenous leiomyomatosis (IL), 5 smooth muscle tumors of uncertain malignant potential (STUMP) and 8 leiomyosarcomas (LMS), to investigate the diagnostic value of MIB-1 and p53 in uterine smooth muscle tumors. RESULTS: The MIB-1 labelling index was low in ULs and their variants (mean 5.67+/-5.53), but it was increased in STUMPs (17.67+/-6.51) and markedly increased in LMSs (35.71+/-11.35). In ULs and their variants, no immunostaining for p53 was noted except in one case of BL, while 2 (40%) of 5 STUMPs and 3 (38%) of 8 LMSs showed positive reactions for p53. There were significant differences among leiomyoma, STUMP and LMS in the MIB-1 labelling index and p53 expression. CONCLUSIONS:These results suggest that both abnormal expressions of p53 and a high MIB-1 labelling index are frequently associated with leiomyosarcoma. Our data also indicate that the classification system of Kempson and Hendrickson is well correlated with the MIB-1 labelling index.
