Changes of Serum soluble ICAM-1 levels in Patients with Lung Cancer.
10.4046/trd.1996.43.4.527
- Author:
Wan Hee YOO
1
;
Yong Chul LEE
;
Yang Keun RHEE
Author Information
1. Department of Internal Medicine, College of Medicine, Chonbuk National University, Chonju, Korea.
- Publication Type:Original Article
- Keywords:
ICAM-1;
Lung cancer
- MeSH:
Cell Adhesion Molecules;
Colon;
Enzyme-Linked Immunosorbent Assay;
Humans;
Intercellular Adhesion Molecule-1*;
Liver;
Lung Neoplasms*;
Lung*;
Melanoma;
Neoplasm Metastasis;
Pancreatic Neoplasms;
Urinary Bladder
- From:Tuberculosis and Respiratory Diseases
1996;43(4):527-535
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cell adhesion molecules have been implicated in the various stages of tumor progression and metastasis. ICAM-1 plays a important roles in cell-cell interactions in inflammatory and immune response of several diseases. Recently, elevated levels of sICAM-1 in circulation was reported as association with liver metastasis in gastric, colonic, gall bladder and pancreatic cancer, with reduced survival in malignant melanoma. This study was performed to measure the sICAM-1 in patients with lung cancer and to evaluate the relations between staging of lung cancer and level of sICAM-1. METHODS: Serum sICAM-1 was measured in 36 patients with lung cancer according to the pathologic types and clinical staging before therapy and in 8 controls with ICAM-1 ELISA kit. RESULTS: Serum sICAM-1 levels were elevated in patients with lung cancer except small cell type. Also progression and metastasis of lung cancer associated with elevation of sICAM-1 levels. CONCLUSION: These results suggest that higher levels of serum ICAM-1 reflect the progression and metastasis of lung cancer and it may be used as a marker with diagnostic and prognostic significance.
