Ki-1 Positive Extranodal NK/T Cell Lymphoma, Nasal Type, Mistaken as Dermatomyositis: A Case Report and Literature Review.
- Author:
Hyun Jung KIM
1
;
Eunah SHIN
;
Jung Yeon KIM
;
Kyeongmee PARK
;
Young Jin YOO
;
Seung Sook LEE
Author Information
1. Department of Pathology, Inje University, Sanggye Paik Hospital, Seoul. hjkim@sanggyepaik.ac.kr
- Publication Type:Case Report
- Keywords:
Extranodal NK/T-cell lymphoma, nasal type;
Dermatomyositis;
Ki-1
- MeSH:
Adult;
Biopsy;
Cytoplasm;
Dermatomyositis*;
Drug Therapy;
Humans;
Leg;
Lymphocytes;
Lymphoma*;
Male;
Muscle Fibers, Skeletal;
Respiratory Insufficiency;
Sepsis;
Ulcer
- From:Korean Journal of Pathology
2007;41(4):278-283
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of a 38-year-old male with extranodal NK/T-cell lymphoma, nasal type, showing unusual clinical and pathological features. The patient was admitted for soft tissue swelling and tenderness in both legs. The patient had been treated intermittently 8 months prior for repeated muco-cutaneous ulcers. A muscle biopsy showed medium-sized atypical lymphoid cells with bizarre nuclei and plump cytoplasm, infiltrating to the skeletal muscle fibers with angiocentricity. The immunoresults were Ki-1+, CD56+, cytoplasmic CD3+, with EBV-in situ hybridization +. The patient rapidly deteriorated and died of sepsis and respiratory failure shortly after initiation of low-dose chemotherapy. A careful review of previous biopsies revealed scarce atypical lymphoid cells around vessels with similar immunoprofiles without the presence of Ki-1 positive cells. This case emphasizes that an extranodal NK/T-cell lymphoma may have a dermatomyositis-like diffuse presentation. Ki-1 co-expression can be an unexpected event in a process of the disease course; however, this should be validated with future studies.
