Prevalence and Clinical Aspects of Sjogren Syndrome in Dry Eye Patients.
10.3341/jkos.2012.53.4.499
- Author:
Jun Sung LEE
1
;
Won CHOI
;
Shin Seok LEE
;
Kyung Chul YOON
Author Information
1. Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Autoantibodies;
Dry eye;
Prevalence;
Sjogren syndrome
- MeSH:
Autoantibodies;
Dry Eye Syndromes;
Eye;
Humans;
Medical Records;
Prevalence;
Sjogren's Syndrome;
Tears
- From:Journal of the Korean Ophthalmological Society
2012;53(4):499-504
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the prevalence and clinical aspects of Sjogren syndrome in patients who were diagnosed with dry eye syndrome in Korea. METHODS: The medical records of patients who were diagnosed with dry eye syndrome in a dry eye clinic during a 2-year period (March 2008 to March 2010) and were followed up for more than 3 months were reviewed retrospectively. RESULTS: A total of 206 patients were included in the present study. Fifty-eight patients (28%) had Sjogren syndrome and 39 patients (19%) showed primary Sjogren syndrome. Sjogren syndrome patients showed poorer results than non-Sjogren syndrome patients in ocular surface disease index score (OSDI), tear break up time, Schirmer test score, and ocular surface staining score using the Oxford scheme (p < 0.05). Among the patients with primary Sjogren syndrome, 27 patients were SSA (anti-Ro antibodies) or SSB (anti-La antibodies) positive and 12 patients were sero-negative. There were no statistically significant differences in objective or subjective parameters between the sero-positive and sero-negative groups. CONCLUSIONS: Sjogren syndrome was observed in 28% of all dry eye patients, in two-thirds of severe dry eye patients. Sjogren syndrome patients showed more severe clinical aspects than dry eye patients with non-Sjogren syndrome. Diagnosing Sjogren syndrome through systemic evaluation is necessary in the patients with severe dry eye.
