Impact of Early Initiation of Dialysis on Clinical Outcome.
- Author:
La Young YOON
1
;
Hyeon Jeong GOONG
;
Se Hun KIM
;
Koung Ah PARK
;
Byung Chul YOU
;
Yu Ri SEO
;
Seung Sik PARK
;
Eun Jung KIM
;
Soo Jeong CHOI
;
Moo Yong PARK
;
Jin Kuk KIM
;
Seung Duk HWANG
Author Information
1. Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. medkjk@schmc.ac.kr
- Publication Type:Original Article
- Keywords:
Early dialysis;
Late dialysis;
Chronic kidney failure
- MeSH:
Dialysis;
Glomerular Filtration Rate;
Humans;
Kidney;
Kidney Failure, Chronic;
Multivariate Analysis;
Renal Dialysis;
Renal Insufficiency;
Retrospective Studies;
Survival Rate;
Uremia
- From:Soonchunhyang Medical Science
2011;17(1):25-28
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Current guidelines for initiating dialysis therapy are based on level of kidney function and clinical evidence of uremia. In several studies, early dialysis showed no benefit in mortality and complication rate. Thus we examined whether the timing of initiation of dialysis influenced mortality and complication rate with renal failure. METHODS: We retrospectively studied the clinical outcomes in 290 patients with renal failure who underwent dialysis therapy from 2001 to 2009. The early and late dialysis group defined as values more than and less than 10 mL/min/1.73 m2. The primary outcome was death from any cause and the secondary outcome was complication event. RESULTS: The survival rates and complication events were compared based on the estimated glomerular filtration rate, the survival rate in late dialysis group is better than in early dialysis group and the significant prognostic factors determined by multivariate analysis were age and residual renal function at time of initiation of dialysis. No difference in complication events were observed. Subgroup analysis in hemodialysis group shows no significant difference in survival rate. CONCLUSION: The survival rate in late dialysis group is better than in early dialysis group. And the complication rate were not different in two groups.
