Association Study between Per3 Gene Polymorphism and Diurnal Preference.
- Author:
Seung Gul KANG
;
TaeYoung CHOI
;
Ho Kyoung YOON
;
Young Min PARK
;
Leen KIM
;
Heon Jeong LEE
- Publication Type:Original Article
- Keywords:
Diurnal preference;
Polymorphism;
PER3;
Morningness
- MeSH:
Alleles;
Female;
Genotype;
Humans;
Polymerase Chain Reaction
- From:Sleep Medicine and Psychophysiology
2011;18(1):35-39
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Diurnal preference is an attribute reflecting whether people are alert and preferring to be active either early or late in the day. It also referred to as chronotype or morningness-eveningness trait. The PER3 genes have been known to influence diurnal preference. In this study, we have investigated the associations between the PER3 gene polymorphisms and diurnal preference in a healthy young population, controlling for the social and environmental confounding factors. METHODS: The participants in this experiment included 299 unrelated medical college students (M=191, F=108), with a mean age of 22.9 years. Diurnal preference was measured by a single administration of the 13-item Composite Scale for Morningness (CSM). Genotyping of the PER3 VNTR (rs57875989) was performed using polymerase chain reaction. A two-tailed alpha of 0.05 was chosen. RESULTS: The mean+/-SD score on the CSM scale for all subjects was 31.90+/-6.39. There was no significant difference in total CSM score between gender groups, although females showed a trend towards higher morningness score. Although PER3 5R/5R showed the tendency towards high CSM scores, there were no significant differences on CSM scores among genotypes and allele status of PER3 VNTR (rs57875989). CONCLUSIONS: We could not confirm that the PER3 VNTR is associated with diurnal preference in a Korean healthy young population. The future studies need to investigate the association between diurnal preference and other polymorphisms of PER3 gene in larger sample of Korean young healthy population.
