Predictors of Recurrent Ductal Carcinoma In Situ after Breast-Conserving Surgery.
10.4048/jbc.2016.19.2.185
- Author:
Jung Yeon KIM
1
;
Kyeongmee PARK
;
Guhyun KANG
;
Hyun Jung KIM
;
Geumhee GWAK
;
Young Joo SHIN
Author Information
1. Department of Pathology, Inje University Sanggye Paik Hospital, Seoul, Korea. kpark@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Breast;
Carcinoma;
Intraductal;
Recurrence
- MeSH:
Breast;
Carcinoma, Ductal*;
Carcinoma, Intraductal, Noninfiltrating*;
Cohort Studies;
Diagnosis;
Estrogens;
Female;
Humans;
Logistic Models;
Mastectomy, Segmental*;
Radiotherapy;
Receptor, Epidermal Growth Factor;
Receptors, Progesterone;
Recurrence;
Risk Factors
- From:Journal of Breast Cancer
2016;19(2):185-190
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Local recurrence is a major concern in patients who have undergone surgery for ductal carcinoma in situ (DCIS). The present study assessed whether the expression levels of hormone receptors, human epidermal growth factor receptor 2 (HER2), and Ki-67, as well as resection margin status, tumor grade, age at diagnosis, and adjuvant hormonal therapy and radiotherapy (RT) are associated with recurrence in women with DCIS. METHODS: In total, 111 patients with DCIS were included in the present study. The invasive and noninvasive recurrence events were recorded. The clinicopathological features; resection margins; administration of hormonal therapy and RT; expression statuses of estrogen receptor (ER), progesterone receptor (PR), and HER2; Ki-67 expression; and molecular subtypes were evaluated. Logistic regression analysis was performed to examine the risk factors for recurrence. RESULTS: Recurrence was noted in 27 of 111 cases (24.3%). Involvement of resection margins, low tumor grade, high Ki-67 expression, and RT were independently associated with an increase in the recurrence rate (p<0.05, Pearson chi-square test). The recurrence rate was not significantly associated with patient age; ER, PR, and HER2 statuses; molecular subtype; and hormonal therapy. CONCLUSION: The results of the present study suggested that the involvement of resection margins, low tumor grade, high Ki-67 index, and the absence of adjuvant RT were independently associated with increased recurrence in patients with DCIS. Future studies should be conducted in a larger cohort of patients to further improve the identification of patients at high-risk for DCIS recurrence.
