Experience with Bilateral Risk-Reducing Mastectomy for an Unaffected BRCA Mutation Carrier.
10.4048/jbc.2016.19.2.218
- Author:
Yurina MAESHIMA
1
;
Kumiko OSETO
;
Ryohei KATSURAGI
;
Yukiko YOSHIMOTO
;
Sachiko TAKAHARA
;
Akira YAMAUCHI
Author Information
1. Department of Breast Surgery, Kitano Hospital Breast Center, The Tazuke Kohukai Medical Research Institute, Osaka, Japan. a-yamauti@kitano-hp.or.jp
- Publication Type:Case Report
- Keywords:
Genes;
BRCA2;
Prophylactic surgical procedure;
Subcutaneous mastectomy
- MeSH:
Adult;
Asian Continental Ancestry Group;
Breast;
Breast Neoplasms;
Female;
Humans;
Mastectomy*;
Mastectomy, Subcutaneous;
Nipples;
Prophylactic Surgical Procedures;
Risk Management;
Skin
- From:Journal of Breast Cancer
2016;19(2):218-221
- CountryRepublic of Korea
- Language:English
-
Abstract:
Women with BRCA1/2 mutations have a high risk of breast cancer and may opt for risk-reducing mastectomy (RRM). We report a 38-year-old Japanese woman who was diagnosed as a BRCA2 mutation carrier. She underwent prophylactic bilateral skin-sparing mastectomy (SSM) with excision of the nipple and preservation of the areola skin. It is unclear whether a bilateral RRM leads to better survival compared with intensive surveillance. The oncological risk associated with the presence of remnant breast glandular tissue after SSM or nipple-sparing mastectomy has been obscure. We report the first case of RRM for a Japanese BRCA mutation carrier and provide a literature review on risk management for BRCA mutation carriers with a focus on the concepts and procedures of RRM.
