A Randomized Controlled Trial of Compression Rates during Cardiopulmonary Resuscitation.
10.3346/jkms.2016.31.9.1491
- Author:
Sung Oh HWANG
1
;
Kyoung Chul CHA
;
Kyuseok KIM
;
You Hwan JO
;
Sung Phil CHUNG
;
Je Sung YOU
;
Jonghwan SHIN
;
Hui Jai LEE
;
Yoo Seok PARK
;
Seunghwan KIM
;
Sang Cheon CHOI
;
Eun Jung PARK
;
Won Young KIM
;
Dong Woo SEO
;
Sungwoo MOON
;
Gapsu HAN
;
Han Sung CHOI
;
Hyunggoo KANG
;
Seung Min PARK
;
Woon Yong KWON
;
Eunhee CHOI
Author Information
1. Department of Emergency Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea. shwang@yonsei.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Cardiopulmonary Resuscitation;
Cardiac Arrest;
Basic Life Support
- MeSH:
Cardiopulmonary Resuscitation*;
Emergency Service, Hospital;
Heart Arrest;
Humans;
Out-of-Hospital Cardiac Arrest;
Outcome Assessment (Health Care);
Resuscitation
- From:Journal of Korean Medical Science
2016;31(9):1491-1498
- CountryRepublic of Korea
- Language:English
-
Abstract:
The objective of this study was to compare the efficacy of cardiopulmonary resuscitation (CPR) with 120 compressions per minute (CPM) to CPR with 100 CPM in patients with non-traumatic out-of-hospital cardiac arrest. We randomly assigned patients with non-traumatic out-of-hospital cardiac arrest into two groups upon arrival to the emergency department (ED). The patients received manual CPR either with 100 CPM (CPR-100 group) or 120 CPM (CPR-120 group). The primary outcome measure was sustained restoration of spontaneous circulation (ROSC). The secondary outcome measures were survival discharge from the hospital, one-month survival, and one-month survival with good functional status. Of 470 patients with cardiac arrest, 136 patients in the CPR-100 group and 156 patients in the CPR-120 group were included in the final analysis. A total of 69 patients (50.7%) in the CPR-100 group and 67 patients (42.9%) in the CPR-120 group had ROSC (absolute difference, 7.8% points; 95% confidence interval [CI], -3.7 to 19.2%; P = 0.183). The rates of survival discharge from the hospital, one-month survival, and one-month survival with good functional status were not different between the two groups (16.9% vs. 12.8%, P = 0.325; 12.5% vs. 6.4%, P = 0.073; 5.9% vs. 2.6%, P = 0.154, respectively). We did not find differences in the resuscitation outcomes between those who received CPR with 100 CPM and those with 120 CPM. However, a large trial is warranted, with adequate power to confirm a statistically non-significant trend toward superiority of CPR with 100 CPM. (Clinical Trial Registration Information: www.cris.nih.go.kr, cris.nih.go.kr number, KCT0000231)
