A case of desmoplastic small round cell tumor.
- Author:
Suk Hwan CHUNG
1
;
Sang Yeob LEE
;
Dong Sung KUM
;
Sung Hyun KIM
;
Hyuk Chan KWON
;
Jae Soek KIM
;
Hyo Jin KIM
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. kimhj@mail.donga.ac.kr
- Publication Type:Case Report
- Keywords:
Small round cell tumor;
Desmoplastic;
Polyphenotypic differentiation
- MeSH:
Abdominal Cavity;
Biopsy;
Biopsy, Fine-Needle;
Cisplatin;
Cyclophosphamide;
Desmoplastic Small Round Cell Tumor*;
Diagnosis;
Doxorubicin;
Drug Therapy;
Etoposide;
Female;
Humans;
Lymph Nodes;
Middle Aged;
Neoplasm Metastasis;
Translocation, Genetic
- From:Korean Journal of Medicine
2003;65(5):610-614
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Desmoplastic small round cell tumor (DSRCT) is a rare neoplasm that develops in the abdominal cavity in young people. Microscopically, nests of small undifferentiated cells within a desmoplastic stroma are observed and immunohistochemical studies show polyphenotypic differentiation with expression of epithelial, neural and muscle markers. A specific chromosomal translocation, t (11;22)(p13;q12) has been documented in DSRCT and is increasingly used to confirm the diagnosis. We had experienced a 59-year-old female with right upper quardrant pain for 1 month. On abdominal computerized tomography, multiple demarcated intrahepatic mass lesions were found, but other organs metastasis or abnormal lymph node enlargement and fluid collection were not found. Fine needle aspiration biopsy of hepatic mass was performed and DSRCT was diagnosed by H and E and immunohistochemical staining. She was treated with cyclophosphamide, etoposide, doxorubicin and cisplatin. After three cycles of chemotherapy, computerized tomography demonstrated distinct shrinkage of tumor. At present, she continues in the state of partial remission for 15months after chemotherapy was started.
