Prevalence and Risk Factors of Hepatitis C Virus Infection in Chronic Hamodialysis Patients(multi-center study).
- Author:
Hyang KIM
1
;
Ki Taek KIM
;
Jong Hyeon YOO
;
Byung Ik KIM
;
Sang Jong LEE
;
Eun Joo LEE
;
Sang Eun PARK
;
Sang Yeol SUH
;
Ja Ryong KOO
;
Sun Sook KIM
;
Dae Ryong CHA
;
Young Joo KWON
;
Won Yong CHO
;
Hyoung Kyu KIM
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Anti-HCV Ab;
CRF;
Hemodialysis
- MeSH:
Blood Transfusion;
Dialysis;
Hepacivirus*;
Hepatitis B Surface Antigens;
Hepatitis C*;
Hepatitis*;
Humans;
Liver;
Prevalence*;
Renal Dialysis;
Risk Factors*
- From:Korean Journal of Medicine
1997;52(6):833-840
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of this study was to evaluate the prevalence and risk factors of hepatitis C virus(HCV) infection in patients on chronic hemodialysis. METHODS: We measured antibody to HCV using second generation enzyme immunoassay(ELISA) test or radioimmunoassay(RIA) and hepatitis B surface antigen, serum values of AST, ALT in 224 patients of six urban hemodialysis units. We also investigated some clinicai parameters such as age, sex, duration and frequency of hemodialysis, the amount of blood transfusion, and hemodialysis of infected patients on separate machines. RESULTS: 1) 33 of 224 patients(14.7%) were positive for HCV antibody. 2) The prevalence of HCV antibody were most significantly correlated with duration of hemodialysis and less significantly with frequency of hemodialysis, amount of blood transfusion but not correlated with age, sex and level of liver enzyme. 3) The prevalence of HCV antibody was significantly higher in a center which did not separate dialysis machine for HCV antibody positive patients than centers which did. CONCLUSION: Th prevalence of HCV antibody was most signficantly correlated with duration of hemodialysis. We suggest that environmental factor of hemodialysis unit may play major role in HCV infection of hemodialysis patients. So the importance of separate dialysis machine from HCV antibody positive patients should be emphasized.
