The Genetic Polymorphism of Alpha 2-Heremans Schmidt Glycoprotein (AHSG), and Antibody to AHSG in Patients with Endometriosis.
- Author:
Hoon KIM
1
;
Jung Gu KIM
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
AHSG;
Endometriosis;
Genetic polymorphism;
Antibody
- MeSH:
Alleles;
Endometriosis*;
Female;
Gene Frequency;
Genotype;
Glycoproteins*;
Humans;
Polymorphism, Genetic*;
Polymorphism, Restriction Fragment Length;
Sequence Analysis, DNA
- From:Korean Journal of Obstetrics and Gynecology
2004;47(5):938-945
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate the relationship among alpha 2-Heremans Schmidt glycoprotein (AHSG) polymorphism, anti-AHSG antibody and endometriosis in Korean women. METHODS: AHSG polymorphism was analyzed by restriction fragment length polymorphism and DNA sequencing in 79 women with endometriosis, and 105 women with normal pelviscopic finding. Anti-AHSG antibody was measured using enzyme linked immuosorbent assay. RESULTS: The allele frequencies of AHSG 1 and AHSG 2 were 0.69 and 0.31 respectively. The proportion of noncarrier of AHSG 2 allele was significantly higher (p<0.05) in women with endometriosis than in women without endometriosis (55.7% versus 39.0%). Women not carrying AHSG 2 allele have 2 times higher risk of endometriosis than women carrying at least one this allele. Positive rate of anti-AHSG antibody was significantly higher in women with endometriosis (20.0%) than women without endometriosis (2.7%). There were no significant differences in the distribution of AHSG allele or AHSG genotypes and in positivity of anti-AHSG antibody between early stage endometriosis and late stage endometriosis. No significant difference in positivity of anti-AHSG antibody was noted among AHSG genotypes. CONCLUSION: AHSG polymorphism and anti-AHSG antibody is associated with endometriosis, but the positivity of anti-AHSG antibody does not depend on AHSG genotypes.
