Clinical importance of F-waves as a prognostic factor in Guillain-Barré syndrome in children.
10.3345/kjp.2016.59.6.271
- Author:
Eung Bin LEE
1
;
Yun Young LEE
;
Jae Min LEE
;
Su Min SON
;
Su Kyeong HWANG
;
Soonhak KWON
;
Sae Yoon KIM
Author Information
1. Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea. sysnow88@hanmail.net
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Guillain-Barré syndrome;
Acute inflammatory demyelinating polyradiculopathy;
F-wave;
Nerve conduction velocity
- MeSH:
Child*;
Fever;
Guillain-Barre Syndrome*;
H-Reflex;
Humans;
Immunoglobulins;
Incidence;
Prevalence;
Prognosis;
Reflex, Abnormal;
Retrospective Studies
- From:Korean Journal of Pediatrics
2016;59(6):271-275
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: A limited number of studies have examined the link between F-wave abnormalities and clinical presentation in pediatric Guillain-Barré syndrome (GBS). Therefore, this study examined the importance of F-wave abnormalities as a prognostic factor in pediatric GBS patients. METHODS: The records and electrodiagnostic studies (EDS) of 70 GBS patients were retrospectively evaluated, and divided into 2 groups according to the results of EDS. Group A (n=33) presented with F-wave abnormalities, and group B (n=26) exhibited normal findings. We compared laboratory reports, clinical features, response to treatment, and prognosis between the 2 groups. RESULTS: Motor weakness was the most frequently observed symptom for either group. Clinically, the incidence of fever and upper respiratory symptoms differed between the 2 groups, while the prevalence of abnormal deep tendon reflex (DTR) was significantly higher in group A than B (P<0.05). Patients diagnosed with GBS had received intravenous immunoglobulin treatment: 94% in group A and 58% in group B. Furthermore, significantly greater numbers of patients in group A showed H-reflex abnormalities and poor prognosis compared with group B (P<0.05). CONCLUSION: This study demonstrated that F-waves are a clinically important prognostic factor in GBS. F-wave abnormalities were associated with abnormal DTR and poor prognosis in patients. Limited studies have examined the link between F-wave abnormalities and clinical results; therefore, further randomized controlled studies are needed to confirm the clinical characteristics and efficacy of treatments.
