A rare case of Sjogren-Larsson syndrome with recurrent pneumonia and asthma.
10.3345/kjp.2016.59.6.276
- Author:
Azita TAVASOLI
1
;
Shirin SAYYAHFAR
;
Babak BEHNAM
Author Information
1. Department of Pediatrics, Iran University of Medical Sciences, Tehran, Iran.
- Publication Type:Case Report
- Keywords:
Asthma;
Ichthyosis;
Leukotriene B4;
Recurrent pneumonia;
Sjogren-Larsson syndrome
- MeSH:
Aldehyde Dehydrogenase;
Asthma*;
Cerebral Palsy;
Child;
Child, Preschool;
Humans;
Ichthyosis;
Incidence;
Intellectual Disability;
Leukotriene B4;
Male;
Metabolism;
Molecular Biology;
Neurocutaneous Syndromes;
Pneumonia*;
Quadriplegia;
Sequence Deletion;
Sjogren-Larsson Syndrome*
- From:Korean Journal of Pediatrics
2016;59(6):276-279
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sjogren-Larsson syndrome (SLS) is a rare autosomal recessive neurocutaneous disorder with worldwide incidence of 0.4 per 100,000 people. It is characterized by the triad of congenital ichthyosis, spastic diplegia or quadriplegia, and mental retardation. Herein we report a 2-year-old male child with SLS, asthma, and recurrent pneumonia. SLS was confirmed by a molecular genetics study that revealed a deletion mutation in the ALDH3A2 gene. An ALDH3A2 gene mutation results in dysfunction of the microsomal enzyme fatty aldehyde dehydrogenase and impaired metabolism and accumulation of leukotriene B4, which is a key molecule and a pro-inflammatory mediator in developing allergic diseases, especially asthma. An increased level of leukotriene B4 has been reported in SLS patients. As far as we are aware, this is the first report of SLS associated with asthma and recurrent pneumonia. In conclusion, pediatricians should be aware of and evaluate patients with SLS for possible associated asthma and allergic disorders.
