Opportunistic Infections and Malignancies in 173 Patients with HIV Infection.
- Author:
Kang Won CHOE
1
;
Myoung Don OH
;
Sang Won PARK
;
Hong Bin KIM
;
Ui Seok KIM
;
Seong Wook KANG
;
Hee Jong CHOI
;
Dong Hyeon SHIN
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Human immunodeficiency virus;
AIDS;
Opportunistic infection;
Malignancy
- MeSH:
AIDS Dementia Complex;
Candidiasis;
Cause of Death;
Centers for Disease Control and Prevention (U.S.);
Cytomegalovirus;
Herpes Zoster;
HIV Infections*;
HIV*;
Hospitals, Teaching;
Humans;
Korea;
Lymphocyte Count;
Lymphoma;
Medical Records;
Opportunistic Infections*;
Peripheral Nervous System Diseases;
Pneumonia;
Pneumonia, Pneumocystis;
Prevalence;
Sarcoma;
Seoul;
Suicide;
Toxoplasmosis;
Tuberculosis;
United States
- From:Korean Journal of Infectious Diseases
1998;30(6):507-515
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The frequency and type of major opportunistic infections (OI' s) in HIV-infected patients are different among various countries. To determine major OI' s in Korea, we analyzed OI' s in HIV-infected patients at an university-affiliated teaching hospital in Korea. METHODS: We reviewed medical records for the HIV-infected patients seen at Seoul National University Hospital from 1985 to April 1998. OI' s were diagnosed according to the definition proposed by CDC (1993). RESULTS: One hundred and seventy three patients were analyzed. Over 70% of the patients were followed for more than 6 months. CD4 + lymphocyte counts at the initial visit ranged 200 to 500/mm 3 in 55% of the patients, and was less than 200/mm 3 in 26%. Tuberculosis was the most frequent OI (25%), followed by candidiasis (21%), herpes zoster (20%), and pneumocystis carinii pneumonia (10%). Kaposi' s sarcoma developed in 3 patients (2%), non-Hodgkin' s lymphoma in 2 (1%). Eleven patients (6%) developed peripheral neuropathy, and 8 patients (5%) had HIV encephalopathy. There was no case of toxoplasmosis. The AIDS defining conditions for the 61 AIDS patients was comprised of 39 (64%) tuberculosis, 6 (10%) esophageal candidiasis, and 6 (10 %) pneumocystis carinii pneumonia. Twenty four patients died; 7 patients died of pneumonia and 4 patients committed suicide. There was no long-term nonprogressor. CONCLUSION: Tuberculosis was the most frequent OI in Korean HIV-infected patients. Candidiasis, herpes zoster, and cytomegalovirus diseases were also common. Compared to those in the United States and European countries, the prevalence of toxoplasmosis and Kaposi' s sarcoma were relatively low. Pneumonia was the major cause of death.
