Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population.
- Author:
Hosik SEOK
1
;
Koo Han YOO
;
Young Ock KIM
;
Joo Ho CHUNG
Author Information
1. Department of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea. jhchung@khu.ac.kr
- Publication Type:Original Article
- Keywords:
Prostatic hyperplasia;
Aldehyde dehydrogenase 2;
Single nucleotide polymorphism
- MeSH:
Aldehyde Dehydrogenase;
Disease Progression;
Gene Frequency;
Genotype;
Humans;
Hyperplasia*;
Metabolism;
Polymorphism, Single Nucleotide*;
Prostate*;
Prostate-Specific Antigen;
Prostatic Hyperplasia
- From:International Neurourology Journal
2013;17(4):168-173
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Aldehyde dehydrogenase 2 (ALDH2) is a well-known gene involved in alcohol and aldehyde metabolism. Moreover, recent studies have reported associations between ALDH2 and age-related disorders. Benign prostate hyperplasia (BPH) is an age-related disorder and genetic factors may contribute to its onset. In this study, we investigated the association of a well-studied ALDH2 single nucleotide polymorphism (SNP), rs671, with the onset and clinical features of BPH. METHODS: A total of 222 BPH patients and 214 control subjects were genotyped. The clinical features of the BPH patients (prostate volume, prostate-specific antigen level, and International Prostatic Symptom Score) were analyzed. RESULTS: The results show that rs671 was only associated with the volume of BPH in genotype and allele frequencies (P<0.05). CONCLUSION: We propose that rs671 is an Asian-specific SNP in ALDH2 that may affect the disease progression of BPH in the Korean population.
