Maintenance of the Therapeutic Effect of Two High-Dosage Antimuscarinics in the Management of Overactive Bladder in Elderly Women.
- Author:
Kirill KOSILOV
1
;
Sergey LOPAREV
;
Marina IVANOVSKAYA
;
Liliya KOSILOVA
Author Information
1. Far Eastern Federal University, Vladivostok, Russia. oton2000@mail.ru
- Publication Type:Original Article
- Keywords:
Overactive urinary bladder;
Older women;
Muscarinic antagonists;
Long-term results
- MeSH:
Aged*;
Electric Stimulation;
Family Characteristics;
Female;
Humans;
Methods;
Muscarinic Antagonists*;
Muscles;
Punctures;
Recurrence;
Solifenacin Succinate;
Urinary Bladder;
Urinary Bladder, Overactive*;
Urodynamics
- From:International Neurourology Journal
2013;17(4):191-196
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To improve the long-term efficiency of the pharmacologic management of overactive bladder (OAB) in elderly women. METHODS: The study comprised 229 women (mean age, 66.3 years; range, 65-77 years) with urodynamically and clinically confirmed OAB. All patients received the most effective treatment regimen based on the data obtained in the initial part of the study (trospium 60 mg/day + solifenacin 40 mg/day, for 6 weeks), and positive results similar to those in the first phase were obtained. They were then divided into four groups, based on the maintenance therapy: group A (59 women), trospium (60 mg/day) + solifenacin (40 mg/day) for 1 month; group B (51 women), electrical stimulation of the detrusor muscle for 1 month; group C (63 women), laser puncture for 1 month; group D (56 women), placebo. Maintenance therapy was administered 2.5 months after completion of primary treatment. The patients' condition was monitored through the OAB questionnaire for 1 year and by urodynamic examination at months 6 and 7 from the start of the study. RESULTS: In group A, the clinical and urodynamic results achieved after the initial + main treatment phase (two high-dosage antimuscarinics of different generations, trospium and solifenacin, for a total of 2.5 months) were maintained for at least 7 months. Electrical stimulation of the urinary bladder as a method of maintenance therapy proved to be less effective. In groups C and D, deterioration in results was observed at 6-8 months, which led us to conclude that laser puncture was an inefficient method of maintenance therapy in elderly women with OAB. CONCLUSIONS: Maintenance treatment of OAB in elderly women with a combination of high-dosage antimuscarinics is an effective method for reducing the risk of recurrence of the disease.
