Experimental Study of Cerebral Protective Action with Dexamethasone in a Rat`s Forebrain Ischemic Model.
10.4097/kjae.1990.23.4.529
- Author:
Sung Seop KIM
1
;
Soung Wan BAIK
;
Inn Se KIM
;
Kyoo Sub CHUNG
Author Information
1. Department of Anesthesiology, College of Medicine, Pusan National University, Korea.
- Publication Type:Original Article
- Keywords:
Two-vessel occlusion method;
Forebrain ischemia;
Hippocampus;
Pathophysiology;
Dexamethasone;
Protective action
- MeSH:
Animals;
Carotid Arteries;
Carotid Artery, Common;
Cerebrum;
Dexamethasone*;
Hippocampus;
Ischemia;
Models, Animal;
Neurons;
Prosencephalon*;
Rats
- From:Korean Journal of Anesthesiology
1990;23(4):529-535
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study examined the protective effect of dexamethansone following bilateral forebrain ischemia in a rat model of two-vessel occlusion. Twenty rats were subjected to dexamethasone (1 mg/kg intravenously) before bilateral common carotid artery occlusion for 10 minutes. Carotid artery blood flow was restored and the rats were terminated by a perfusion-fixation method after 7 days. Ten minutes of two-vessel occlusion produced cellular ischemic change in the cerebral hemispheres of most rats. This region was studied mainly with light microscope, and it was noticed that the CA 1 neuron in the hippocampus is the most vulnerable to ischemia. Ischemic neuronal damage was graded in accordance with conventional neuropathological criteria. The grade had no statistical significance.
