Activation of Innate Immune System During Viral Infection: Role of Pattern-recognition Receptors (PRRs) in Viral Infection.
10.4167/jbv.2009.39.3.145
- Author:
Eun Jung JUN
1
;
Yoo Kyum KIM
Author Information
1. Department of Microbiology, University of Ulsan College of Medicine, Seoul, Korea. ykkim@amc.seoul.kr
- Publication Type:Review
- Keywords:
Innate immunity;
Viral infection;
Toll-like receptor;
RIG-I-like receptor;
PAMP
- MeSH:
Adaptive Immunity;
Immune System;
Immunity, Innate;
Interferon Regulatory Factors;
Porcine Reproductive and Respiratory Syndrome;
Signal Transduction;
Toll-Like Receptors
- From:Journal of Bacteriology and Virology
2009;39(3):145-157
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Innate immunity and adaptive immunity are two major immune responses against pathogens. Innate immunity is responsible for the immediate immune response to pathogens. Pattern-recognition receptors (PRRs) play an important role in innate immune response. PRRs recognize regular patterns of molecule structure known as pathogen-associated molecular patterns (PAMPs). Among the PRRs, Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and DNA-dependent activator of interferon regulatory factors (DAI) display key roles in response to viral infections. This article reviews how viral infections activate PRR-PAMP signal pathways and how viruses evade immune responses elicited by PRR signal pathways.
