Animal Experiments of Heart Transplantation for Complicated Congenital Heart Disease in Neonate.
- Author:
Young Hwan PARK
1
;
Chee Soon YOON
;
Won Suk JUNG
;
Myung Ok KIM
;
Bum Koo CHO
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Heart transplantation;
Infant, neonate;
Heart defect, congenital
- MeSH:
Adult;
Animal Experimentation*;
Animals*;
Aorta;
Aorta, Thoracic;
Cardiopulmonary Bypass;
Heart Atria;
Heart Defects, Congenital*;
Heart Transplantation*;
Heart*;
Hemorrhage;
Humans;
Hypoplastic Left Heart Syndrome;
Infant, Newborn*;
Models, Animal;
Mortality;
Pulmonary Artery;
Tissue Donors
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
1999;32(6):504-509
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Heart transplantation is considerated for a selected certain group of complicated congenital heart disease in neonates because corrective surgery is very difficult and has high mortality. Precise planning of transplantation is necessary to adequately fit the donor heart to the recipient. MATERIAL AND METHOD: We have performed 4 neonatal pig heart transplantations to test the technical feasibility. Experiment 1: The transplantation was performed using the same technique as the adult heart transplantation. Experiment 2: The transplantation for hypoplastic left heart syndrome was simulated as we reconstructed the whole aortic arch with donor aorta. Experiment 3: The heart transplantation was done with radical pulmonary artery reconstruction. Experiment 4: The experiment was performed for a long term survival. RESULT: Preoperative planning was very important for adequate fitting. All animals could be weaned from cardiopulmonary bypass, however, two animals died due to bleeding at pulmonary artery and left atrium. CONCLUSION: We concluded that the neonatal heart transplantation can be applied in some complicated Further using animal model is mandatory.
