Cardioprotective Effect of Fimasartan, a New Angiotensin Receptor Blocker, in a Porcine Model of Acute Myocardial Infarction.
10.3346/jkms.2015.30.1.34
- Author:
Doo Sun SIM
1
;
Myung Ho JEONG
;
Ho Chun SONG
;
Jahae KIM
;
Ari CHONG
;
Hee Seung BOM
;
In Seok JEONG
;
Sang Gi OH
;
Jong Min KIM
;
Dae Sung PARK
;
Jung Ha KIM
;
Kyung Seob LIM
;
Min Suk KIM
;
Shi Hyun RYU
;
Hyun Kuk KIM
;
Sung Soo KIM
;
Su Young JANG
;
Jae Yeong CHO
;
Hae Chang JEONG
;
Ki Hong LEE
;
Keun Ho PARK
;
Nam Sik YOON
;
Hyun Ju YOON
;
Kye Hun KIM
;
Young Joon HONG
;
Hyung Wook PARK
;
Ju Han KIM
;
Youngkeun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. The Heart Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health, Welfare and Family Affairs, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Angiotensin-Converting Enzyme Inhibitors;
Angiotensin Receptor Blockers;
Myocardial Infarction
- MeSH:
3-Iodobenzylguanidine;
Angiotensin II Type 1 Receptor Blockers/therapeutic use;
Angiotensin Receptor Antagonists/*therapeutic use;
Angiotensin-Converting Enzyme Inhibitors/therapeutic use;
Animals;
Anterior Wall Myocardial Infarction/*drug therapy/physiopathology;
Biphenyl Compounds/*therapeutic use;
Cardiotonic Agents/*therapeutic use;
Disease Models, Animal;
Echocardiography;
Fluorodeoxyglucose F18;
Perindopril/therapeutic use;
Positron-Emission Tomography;
Pyrimidines/*therapeutic use;
Random Allocation;
Swine;
Tetrazoles/*therapeutic use;
Tomography, Emission-Computed, Single-Photon;
Valsartan/therapeutic use;
Ventricular Function, Left/*physiology
- From:Journal of Korean Medical Science
2015;30(1):34-43
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cardioprotective effect of fimasartan, a new angiotensin receptor blocker (ARB), was evaluated in a porcine model of acute myocardial infarction (MI). Fifty swine were randomized to group 1 (sham, n=10), group 2 (no angiotensin-converting enzyme inhibitor [ACEI] or ARB, n=10), group 3 (perindopril 2 mg daily, n=10), group 4 (valsartan 40 mg daily, n=10), or group 5 (fimasartan 30 mg daily, n=10). Acute MI was induced by occlusion of the left anterior descending artery for 50 min. Echocardiography, single photon emission computed tomography (SPECT), and F-18 fluorodeoxyglucose cardiac positron emission tomography (PET) were performed at baseline, 1 week, and 4 weeks. Iodine-123 meta-iodobenzylguanidine (MIBG) scan was done at 6 weeks for visualization of cardiac sympathetic activity. Left ventricular function and volumes at 4 weeks were similar between the 5 groups. No difference was observed in groups 2 to 5 in SPECT perfusion defect, matched and mismatched segments between SPECT and PET at 1 week and 4 weeks. MIBG scan showed similar uptake between the 5 groups. Pathologic analysis showed similar infarct size in groups 2 to 5. Infarct size reduction was not observed with use of fimasartan as well as other ACEI and ARB in a porcine model of acute MI.
